Fibrin glue: an anti-fibrotic agent for contracted socket

Background: The contracted socket is caused by fibrosis leading to the shortening of orbital tissue. Vascular endothelial growth factor (VEGF) a profibrotic in postoperative wound healing. novel option prevent use fibrin glue. This study aims evaluate role glue reducing VEGF expression cells that cause post-socket surgery scar. Methods: An vivo experimental using an animal model was conducted. We used twenty eyes white rabbit species as sample. evisceration carried out and distributed animals four groups consisting control group, MMC group (0.1 ml mitomycin-C (MMC) 0.4 mg/ml), triamcinolone acetonide (TCA) TCA 40 (0,1 glue). treatment performed through injection subconjunctival. After 14 days, rabbits were euthanized, conjunctiva samples cut. Immunoreactivity scores (IRS) analyze epithelia with significant level p <0.05. Data analyzed SPSS version 26 for Windows. Results: All showed statistically difference p-value 0,000 (p<0,05). significantly lower three compared group. highest followed glue, found differences between groups; (p=0.001), (p=0.002), (p=0.005). While could not be proven statistically. Conclusion: Fibrin reduce marker fibrosis; thus, can alternative anti-fibrotic agent.